Finally, we found patients with overexpression of Keap1 and Nrf2 had not significantly worse overall survival by Kaplan–Meier analysis. Significant relationship between Nrf2 and Prd圆 was also detected. Furthermore, we checked the relationship among these oxidative stress markers and found that Keap1 was significantly correlated with Nrf2, Prd圆 and CD147. Expression of Keap1, Nrf2 in tumors was not found to be significantly associated with T category, lymph node metastases, and pathological grade. Expression of oxidative stress markers Keap1, Nrf2, and antioxidants PPIA, Prd圆, as well as CD147 was found to increase consecutively from normal oral mucosa to OSCC, and the Keap1, Nrf2, PPIA, Prd圆, CD147 expression in OSCC were significantly higher when compared to normal oral mucosa. The association among these proteins and pathological features were analyzed. Tissue microarrays containing 17 normal oral mucosa, 7 oral epithelial dysplasia and 43 OSCC specimens were studied by immunohistochemistry. This study aimed to investigate the correlation of oxidative stress markers Keap1 and Nrf2 expression and pathological features in OSCC by using tissue microarray.

However, the role and clinical significance of oxidative stress markers Keap1 and Nrf2 in oral squamous cell carcinoma (OSCC) has not been elucidated. Oxidative stress has been reported to play an important role in progression and prognostication in various kinds of cancers.

Mann whitney u test graphpad prism 5